synthesis and biological evaluation of novel quinoline derivatives as antibacterial and antifungal agents
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abstract
vilsmeier several diamide derivatives containing 2-chloroquinoline scaffolds were synthesized via ugi reaction of 2-chloroquinoline-3-carboxaldehydes, amines, carboxylic acids and isocyanides. the diversity of these quinolinyl ugi-adducts was increased by using 2-chloroquinoline-3-carboxylic acids as a source of acid. among them, compounds 2d, 2n, 2p, 4a, 4c and 4e displayed moderate to good antibacterial and antifungal activity.
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Journal title:
organic chemistry researchجلد ۲، شماره ۲، صفحات ۱۱۳-۱۱۹
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